SEARCH
Sebastian Rushworth MD: Do drug trials underestimate side effects?
Related: atherosclerosis, auto-immune disease, ethics in medicine, gears of the machine, health, SARS-CoV-2 aka COVID-19 aka Coronavirus, Sebastian Rushworth MD, statin
re: Vaccine Safety: “fewer than 1% of vaccine adverse events are reported”
re: The Dismal Anti-Science of Modern Medicine: “less than 0.3% of all adverse drug events and 1-13% of serious events are reported to the Food and Drug Administration”
re: No Plans to Develop Database for Post-COVID-19 Experimental Vaccination Deaths: FDA
re: Sebastian Rushworth MD
Should not be a surprise to anyone who understands how the world works.
Do drug trials underestimate side effects?
by Sebastian Rushworth M.D., 19 July 2021. Emphasis added.
One commonly used trick in drug trials is to exclude any group that might make the drug look worse, such as those that are more likely to experience side effects. A good recent example of this is the COVID vaccine trials, which largely excluded people with auto-immune diseases (more likely to develop an auto-immune disease after vaccination), people with allergies (more likely to have an allergic reaction to the vaccine), and, of course, the elderly (less likely to develop immunity after getting the vaccine, and more likely to become seriously sick from it).
These three groups are all frequently excluded from trials, and the exclusion is particularly galling when it comes to the elderly, because they are a big segment of the population, and they are also usually the most likely to end up actually using the drugs being tested.
When drug companies have gotten a drug approved, and move on to market the drug, they will studiously avoid mentioning the fact that large segments of the population were excluded from the trials. When drug reps show their flashy powerpoints to gatherings of doctors, say for a new drug to lower blood pressure, they will always present impressive looking graphs of benefit, and they will of course point out how safe their drug was shown to be in the trials. Not once will they mention that the groups of patients the doctors will primarily be prescribing the drug to weren’t even included in the trials.
The doctors will then happily go off and prescribe the drug to multi-morbid 90 year olds, which might explain why prescription drugs are now the third leading cause of death in the western world.
The manipulation of who is included in trials is probably one of the main reasons why findings of side effects always end up being much higher in reality than in clinical trials. It might explain, for example, why muscle pain is a massively common side effect of statins in the real world, while being vanishingly rare in the statin trials (as Dr. Malcolm Kendrick has written about in detail).
...
Drug trials do not accurately represent rates of adverse events. It is likely that the true rate of side effects is often many times higher than that seen in drug trials.
WIND: better health comes from two things: first, practices like nutrition and excercise that are the ONLY approach that can ever bring health—no drug can. Second, that most prescription drugs are fraudulent in terms of the claimed risks and benefits. Think statins and anti-depressants, just for starters.
The FDA, whose purpose is purportedly to protect the public, is in fact complicit in drug trial scams in myriad ways. It’s professional incompetence to not require testing of a new drug on its target population, and yet that is exactly what is done. Let alone drug interactions. Let alone the failure to track side effects.
Vaccine Safety: “fewer than 1% of vaccine adverse events are reported”
No Plans to Develop Database for Post-COVID-19 Experimental Vaccination Deaths: FDA
Follow the money: Big Pharma, the FDA and doctors with financial interestes in drug trials all collude to persuade rank-and-file doctors to prescribe risky and ineffective “treatments”. Once a drug is approved, a massive full court press is put in motion to foist the new poison on millions. Which is why we have massively expensive public health disaster on our hands for decades now, for no demonstrable benefit. Along with overdiagnosis, it’s a massive problem.
As I have auto-immune issues, I am extremely reluctant to get the COVID vaccine. Just as stated, those with such issues were excluded from the trials, and the CDC has explicitly stated “no data”. Somewhere around 10 million Americans have auto-immune issues!
The smart move with ALL drugs is to use them only when absolutely necessary as a last resort when the evidence is overwhelmingly in favor in risk/reward terms, which is absolutely not the case the vast majority of drugs consumed today.
* The efforts involved recommended treatment protocols (mandatory for many doctors), insurance companies, seminars, financial incentives, character assasination of doctors who disagree, etc.
