I’m not qualified to assess all of the claims here, and I wonder how this holds up now, 7 months after its May 2021 date?
2021-05-12, by Anonymous, MD,1 Sucharit Bhakdi, MD, and Michael Palmer, MD.
1. Introduction: All antibodies are not created equal
There are different types of antibodies utilized by the human immune system. The major ones are IgM, IgG and IgA ; there are two other classes, IgD and IgE, but there is no need to discuss them here.
IgM is generated in the early stages of an adaptive immune response and is then gradually replaced with IgG antibodies. Both IgM and IgG circulate mainly in the bloodstream. IgG is the most abundant antibody in the blood. On the other hand, while some IgA is found in the bloodstream as well, most IgA is secreted across the mucous membranes of the respiratory tract and the gut, which it then covers and protects.
2. Why is sIgA antibody important?
The key reason why an sIgA-based antibody response is desired against respiratory pathogens is that sIgA does not promote inflammation... Since our respiratory tract constantly encounters viruses and bacteria within the air we inhale, IgA-based immune responses help avoid unnecessary and repeated inflammations in our airways. sIgA in the mucous membranes of the respiratory tract can subdue the infection and stop the transmission of these germs safely...
3. What is really damaging our body: viruses, or our own immune system?
Respiratory viruses rarely cause direct damage to our body. It is typically the overreaction of our immune system against those viruses that does the damage [2,3]...
4. The route of vaccination matters
A vaccine that is given by intramuscular (IM) injection will mainly induce IgG antibodies in the blood; this matches the body’s response to pathogens introduced by the same route. It is well known that IM vaccines generate very little or no sIgA in the respiratory tract. Therefore, IM injection is not an efficient way of prepping our immune system against respiratory viruses...
5. An IgG response can be a bad thing
Not only does IgG circulating in the bloodstream fail to prevent infection with respiratory viruses, but an IgG-based immune response can even elicit harmful inflammatory responses, causing serious tissue damage within the respiratory tract. In their recent review article on mucosal immunity to COVID-19, Russell et al. state :
Most attention has been given to virus-neutralizing antibodies, especially circulating antibodies. However, these can only be effective in the prevention of infection or disease if [the antibodies] reach the mucosal surfaces where the virus is present, and it should be noted that circulating IgA, even in polymeric form, is not effectively transported into secretions...
7. Vaccination and Th2-type immunopathology
...It is therefore significant that several experimental vaccines against the original SARS virus, while inhibiting proliferation of the virus within the lungs to some degree, caused Th2-type lung pathology, characterized by increased numbers of eosinophil granulocytes within and aggravated injury to the lungs [15–17]. These results indicate that the experimental vaccines against SARS-CoV may cause more severe illnesses when the vaccinated person is challenged with the real virus... We must stress again that SARS-CoV and SARS-CoV-2 are highly homologous, which means that any risk or problem known with SARS-CoV must be considered with SARS-CoV-2 also. While the manufacturers Pfizer, Moderna, and Johnson & Johnson claim that their vaccines preferentially induce Th1 responses, supporting data from human vaccinees are scarce or lacking altogether
All of the currently used COVID vaccines are applied by intramuscular injection, and they are therefore unable to prevent infection of the upper airways with the SARS-CoV-2 virus. In fact, in their clinical trials, none of the manufacturers even attempted to demonstrate efficacy against infection or transmission in their clinical trials [18–21], and the total lack of efficacy in the real world has since been documented in a large study published by the CDC .
The vaccines can, however, lead to severe respiratory immune disease, including Th2-type immunopathology and autoimmunity. When factoring in the large number of adverse events that are being reported with the current vaccines and the low case fatality rate of COVID-19, which we have discussed elsewhere , it is clearly more scientific and more reasonable to strive for herd immunity by natural infection rather than vaccination.
WIND: I suppose it all depends on the type of virus. We do have pertussis vaccines after all, that work very well, or so I assume. But it is also abundantly clear that while vaccines appear to have been protective (hospitalization, deaths), they also have led to a massive wave of infections among the vaccinated—a pandemic of the vaccinated.
At the least, the idea that an intra-muscular injection can yield the same quality and type of immune response as an infection is dubious at best. For at least two reasons.
First, the human immune system surely has developed over eons to detect invaders in the airways (nose, mouth, tonsils, lungs, etc). This early warning system is surely highly relevant.
Second, directly injecting an mRNA virus with spike protein gives the body no heads-up from this early warning system; it’s a direct sudden-onset shock to the system.