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Hiding in Plain Sight: Modern Thiamine Deficiency

re: nutrition

In the context of the nutrient-poor and poisoned modern food supply, this ancient advice is superior by leaps and bounds to anything coming from the medical profession:

Let food by thy medicine, and medicine by thy food”.

Hiding in Plain Sight: Modern Thiamine Deficiency

2021-0929, by Chandler Marrs, and  Derrick Lonsdale

Thiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial energetics—the production of adenosine triphosphate (ATP). It is a critical and rate-limiting cofactor to multiple enzymes involved in this process, including those at the entry points and at critical junctures for the glucose, fatty acid, and amino acid pathways. It has a very short half-life, limited storage capacity, and is susceptible to degradation and depletion by a number of products that epitomize modern life, including environmental and pharmaceutical chemicals.

he RDA for thiamine is 1.1–1.2 mg for adult females and males, respectively. With an average diet, even a poor one, it is not difficult to meet that daily requirement, and yet, measurable thiamine deficiency has been observed across multiple patient populations with incidence rates ranging from 20% to over 90% depending upon the study.

This suggests that the RDA requirement may be insufficient to meet the demands of modern living. Inasmuch as thiamine deficiency syndromes pose great risk of chronic morbidity, and if left untreated, mortality, a more comprehensive understanding thiamine chemistry, relative to energy production, modern living, and disease, may prove useful

Classically defined thiamine deficiency (TD) disorders in the context of alcoholism and malnutrition are familiar, taught in science and health textbooks from high school onward, and yet, for all of that familiarity, not only are most severe cases of deficiency missed, but the early stages, where symptoms are most easily treated, are entirely disregarded []. .. . Decades of research data, discussed later in this paper, suggest that it is not and find overt deficiency in large swaths of patient populations not designated as being at risk via familiar parameters. These individuals are not underfed and they are not likely to consume less than the RDA recommended amount of thiamine. Indeed, they are more likely to be overfed, sometimes obese, and to consume sufficient thiamine based on the current RDA values. This begs many questions, not the least of which is whether we are conceptualizing nutrient deficiency too rigidly.

...

2.1. Symptoms

The early symptoms of TD are non-specific and may be easily attributed to any number of disease processes. Unrelenting or uncharacteristic fatigue, changes in mood with a tendency towards hyper-irritability and mood lability are common []. A sense of mental fuzziness and subtle decrements in memory are often reported, along with loss of appetite, sleep disturbances and/or gastrointestinal (GI) discomfort and dysmotility. Food intolerances and vomiting may develop as the deficiency progresses. Experimental [] and case literature [] suggest GI discomfort and dysmotility may be more prevalent early indications of TD than currently appreciated....

...

DIGLLOYD: could thiamine deficiency be related to COVID deaths?

RDA barely staves off symptoms

The RDA (Recommended Daily Allowance) is a dangerously crude guideline that fails to account for body size, activity level, age, personal variation, bioavailability, and much more.

And for many if not most nutrients, it is really the MDA — Minimum Daily Allowance to forestall clinical symptoms. In other words, meeting the RDA (MDA) will put many people into a state if ill health just short of showing overt clinical symptoms.

The GHA (Good Health Allowance) for most nutrients is surely 2X to 10X the RDA.

Good health ≠ bandaids on breakdowns

It is said that doctors get less than a week of training in nutrition. Shocking. Well, not really—follow the money and follow the human need to be right, facts be damned. Medical training and practice is overwhelmingly about one symptom, one diagnosis, one drug... which might be for the best given the abysmal state of nutritional knowledge in the profession. The profession that consistently gives the worst advice possible, injuring and killing tens of millions (eg the the low fat diet insanity). And don’t get me started on COVID “treatments” or the gross ignorance of magnesium deficiency.

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