Recommended book: The Paleo Thyroid Solution, by Elle Russ @AMAZON. Elle does consulting also, which might be very helpful to those with thyroid conditions. It was her suggestion that in my particular case that the Naltrexone option might be good to try first. You’ll still need to work with a doctor of course.
UPDATE, day 30
See last month’s inital impressions post on Low-Dose Naltrexone.
Energy levels have slowly improved, with yesterday showing the best on-bike energy in 2 months. While it fatigued me, I was able to do two ascents of ~13 minutes each at 220 watts and 231 watts, power levels that used to be routine for up to 10 ascents, but that now greatly exceed my pathetic abilities in July/August (140 to 180 watts). Along with hugely improved subjective feel—a sense of relative ease vs mind-over-matter battle. None of which is cardiovascular (as proven by objective data), it being purely an energy level thing.
I am absolutely better on average, with increasing consistency and fewer and fewer half-awake half-alive days—none for a week now. On average, things are far better than one month ago.
However, there is NO WAY to know if this is just one more in a series of remissions, or real improvement. A significant pattern change will require at least 3 months of steady feel-good to make a tentative conclusion that the low-dose Naltrexone might be causative.
The improvement has not been abrupt as it was in all prior remissions, so it is possible that this time I am seeing a steady positive effect from the Naltrexone. At this point, I am not ready to make any claims for the Naltrexone other than it appears to have some degree of positive effect.
Side effect? My morning resting heart rate has been in a steady one-month uptrend, now being 51 on average, whereas all my life it has hovered around 46 (when very well rests, it is typically 43 and as low as 40). However, activity level and perhaps seasonality could influence it. But if the uptrend continues, that’s a definite physiological change.