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NEJM: A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination

re: ethics in medicine

Real science is never settled, and anyone who has certainty on such things is not qualified to discuss it.

Cracks are opening in the narrative... some people are harmed by the vaccines, and research is needed. Why do we insist that healthy young people take on such risks, given the pathetic state of scientific inquiry and discourse?

NEJM: A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination


The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is incompletely understood, with its effects on multiple organ systems1 and the syndrome of “long Covid” occurring long after the resolution of infection.2 The development of multiple efficacious vaccines has been critical in the control of the pandemic, but their efficacy has been limited by the appearance of viral variants, and the vaccines can be associated with rare off-target or toxic effects, including allergic reactions, myocarditis, and immune-mediated thrombosis and thrombocytopenia in some healthy adults. Many of these phenomena are likely to be immune-mediated.3 How can we understand this diversity in immune responses in different persons?


It would therefore be prudent to fully characterize all antibody and T-cell responses to the virus and the vaccines, including Ab2 responses over time. Using huACE2 transgenic mice and crossing them with strains that are predisposed to autoimmunity or other human pathologic conditions can also provide important insights. An understanding of potential Ab2 responses may also provide insights into Ab1 maintenance and efficacy and into the application of antibody-based therapeutic agents. However, much more basic science research is needed to determine the potential role idiotype-based immunoregulation of both humoral and cell-mediated responses may play both in antiviral efficacy and in unwanted side effects of both SARS-CoV-2 infection and the vaccines that protect us from it.

WIND: you cannot trust the government, and until concerns like this are proven unwarranted, I remain on the side of offering non-coercive vaccinations to the high-risk and those that want them, and while avoiding the child abuse of forced childhood vaccinations, etc. There is just too much potential harm, and too little science (of a pathetic quality, IMO).

Association is not proof (eg correlation is not causation). But this is precisely why you cannot trust the “experts”, who are corrupted intellectually by their roles as spokespersons. We need solid research. We do NOT need to harm those at nil risk of COVID infection. And we might even be harming them more by vaccinating them (short-duration half-assed immunity at the price of potentially severe side effects). The answer is not obvious, not even to the most qualified experts. And it certainly cannot be obtained by eliminating control groups or not studying the issues and using sleights of hand such as timing windows. Two or three years hence, the expert viewpoint could quite different, and at the least, far more nuanced.

No objective scientist or doctor can dismiss concerns along these lines and similar, and any that do should be regarded as quacks, on the basis of their anti-science anti-inquiry viewpoint.

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