My Personal Health: Cyclical Extreme Fatigue Explained: Diagnosis of Hashimoto’s Thyroiditis and Epstein Barr Virus (EBV)
Update: see things that I think are helping.
It’s not welcome news, but I finally have insight into the debilitating cyclical fatigue cycles I’ve been having—the last 6 weeks have been particularly unproductive and frustrating, but it was really severe for a week in June and also back in mid-April when I thought it might be COVID-19—apparently not.
The two things might not be coincidental.
Based on the present studies, EBV infection can cause autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis (MS), rheumatoid arthritis (RA), Sjögren’s syndrome, and autoimmune hepatitis. The EBV has also been reported in patients with autoimmune thyroid disorders. Although EBV is not the only agent responsible for the development of autoimmune thyroid diseases, it can be considered a contributory factor.
We assume that high prevalence of EBV infection in cases of Hashimoto's and Graves' diseases imply a potential aetiological role of EBV in autoimmune thyroiditis. The initiation of autoimmune thyroiditis could start with EBV latency type III infection of follicular epithelium characterised by LMP1 expression involving the production of inflammatory mediators leading to recruitment of lymphocytes.
Tests and prognosis
With a thyroid peroxidase antibody test (“Thyroid Perox AutoAb”) result of 233 IU/ml vs a cutoff of 60, my doctor tells me that confirms a diagnosis of Hashimoto’s Thyroiditis. Which one of my daughters has suffered from for years, long a source of distress for me as a parent (no parent likes seeing a child suffer). So far, my T3 and T4 hormones are at normal levels.
Also a positive antibody test (“EBVNA Ab,IgG Qual”) for recent Epstein Barr Virus (aka mononucleosis), which is odd since I literally touched no one for four months from March through June. Since apparently EBV can lie dormant and erupt again, I now wonder if my hard core ultra endurance efforts periodically triggered it—that would explain fatigue cycles over the years that I could not otherwise explain.
Besides fatigue, some joint paint and aches mean I’ll have to do a lot of resting/sleeping, which is a bit tough when hiking in the mountains soon for my photography work. Maybe I will take a lightweight sleeping pad, and take a solid nap mid-day out there somewhere, plus give up days when I don’t feel strong. I am hoping that I can resume double centuries next spring.