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Reader Comment: COVID-19 Helped by NAC? (N-Acetyl Cisteine)?

N-acetyl Cysteine still seems to be available online in a few places.

Acetylcysteine, also known as N-acetylcysteine (NAC), is a medication that is used to treat paracetamol (acetaminophen) overdose, and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia and bronchitis.[2] It can be taken intravenously, by mouth, or inhaled as a mist.[2] Some people use it as a dietary supplement.[6][7]

Despite my fatigue issues of Long-Haul COVID, my lungs are as good as they have been in 35 years thanks to magnesium supplementation. So NAC does appeal to me.

Anon writes:

I was in the process of ordering some supplements via Amazon, and noticed that Amazon is no longer carrying NAC (N-acetyl Cysteine). I’ve been taking NAC for about a year, mostly for it’s antioxidant properties. In doing a very, very brief web search on NAC discontinuation at Amazon (specifically “amazon” “nac”), I ran across two (2) articles that I thought might be of interest to you, both from the political side and scientific side (specifically for your long-haul issues).

I am fully aware that this is mostly speculation, but the coincidence is just cannot be overlooked (in my opinion).

First article I read (which quotes some of the second article):
The Real Reason ‘NAC’ Supplement Got Banned

In-article link to the scientific paper, SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 via the American Heart Association (AHA) Journals:


  • Timeline: FDA issues warning letter in 2020, saying NAC cannot be legally marketed as a dietary supplement. The AHA article is posted in March 2021. Amazon pulls NAC products in May 2021.
  • To quote the AHA article: “These changes of pACE2, ACE2, MDM2 expression, and AMPK activity in endothelium were recapitulated by in vitro experiments using pulmonary arterial ECs infected with Pseu-Spike which was rescued by treatment with N-acetyl-L-cysteine, a reactive oxygen species inhibitor (Figure [B], ii).” 
  • Second article:
    FDA Protects Covid-19 Vaccine Makers Seeks Withdrawal Of Competing Dietary Supplement

  • “The regulatory statute that authorizes emergency use of vaccines carries with it the caveat that as long as “there are no adequate approved and available alternatives.”  NAC may just be such an alternative that would block emergency use of COVID-19 vaccines.”
  • “... clinicians writing in the British Medical Journal alert the medical community that ‘a distinctive feature of COVID-19 is the presence of mucus plugs in the respiratory tract that explain the severity of this disease… we recommend treatment with NAC to relieve bronchial obstruction.’”
  • “A report published in the journal Therapeutics & Clinical Risk Management proposes 600 milligrams/day of NAC would prevent COVID-19, particularly for health care workers who are repeatedly exposed to infected patients, says a report in Future Microbiology.”
  • “Several scientific reports are coming to the conclusion “the oral administration of NAC is likely to attenuate (reduce) the risk of developing COVID-19.”  Numerous clinical trials are underway to sort out NAC’s ability to quell COVID-19 coronavirus infection.”

WIND: when people are dying from a mutating virus, what business does the FDA have taking a supplement that might help off the market without strong evidence of harm? Especially one that has been used extensively for a long time with no such evidence.

Things like this feed into the idea that the FDA is keen on protecting profits of Big Pharma.

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