PubMed: Short-term Magnesium Deficiency Downregulates Telomerase, Upregulates Neutral Sphingomyelinase and Induces Oxidative DNA Damage in Cardiovascular Tissues: Relevance to Atherogenesis, Cardiovascular Diseases and Aging
See prior posts on magnesium and magnesium deficiency.
Short-term Magnesium Deficiency Downregulates Telomerase, Upregulates Neutral Sphingomyelinase and Induces Oxidative DNA Damage in Cardiovascular Tissues: Relevance to Atherogenesis, Cardiovascular Diseases and Aging
Summary below from Dr. Carolyn Dean, M.D., N.D.
Aging and Magnesium Deficiency
It’s common knowledge that over the age of sixty-five, many people show metabolic decline, with the appearance of atherosclerosis, hypertension, cardio vascular diseases, and type 2 diabetes, culminating in congestive heart failure. All of the attributes of aging have been associated clinically and experimentally with magnesium deficiency. The authors make the following very important observation: “The aging process is also associated with an increase in the levels of proinflammatory cytokines in tissues and cells all present in Mg-deficient animals, tissues, and different cell types.”
Oxidative Stress, Telomerase, and the Heart Certain markers of oxidative stress appear in cardiovascular tissues and DNA with an accompanying decrease in ionized magnesium levels. This indicates that magnesium deficiency could lead to multiple mutations in the genomes of multiple cell lines. The Alturas’ study shows that magnesium deficiency shaves off the ends of telomeres, which can be equated with aging and cardiovascular changes including hypertension, decreased ejection fraction, and cardiac failure.
Magnesium Deficiency and Endothelial Damage Studies by the Alturas in the late 1980s demonstrated changes in the endothelial lining of blood vessels due to magnesium deficiency. The Alturas say that magnesium’s importance in controlling microcirculation and in lipid buildup in the arterial walls is still being overlooked by the next generation of researchers.
[WIND: more like willfully ignored by sticking to dogmatic mainstream echo-chamber status-based “thinking”, a de-facto proof of systemic ethical misconduct in the research field, see recommended books].
Magnesium Deficiency and Chronic Stress Recent studies confirm that short-term magnesium deficiency causes marked reduction in heart cellular glutathione and in cells activating nitric oxide synthases that protect DNA. These findings support the theory that magnesium deficiency can cause mutations in many types of cells.
Magnesium Deficiency and Heart Failure All studies to date have confirmed, experimentally and clinically, that congestive heart failure is an inevitability by age seventy-five to eighty-five for people in magnesium-deficient states.
Magnesium and Cell Signaling for the Heart In the mid-1990s, the Alturas theorized that magnesium ions function as extracellular signals in the pathobiology of cardiovascular disease. A total of forty-two studies now support that theory. Magnesium has a critical role in the regulation of cardiac hemodynamics; vascular tone and reactivity; endothelial functions; carbohydrate, nucleotide, and lipid metabolism; prevention of free radical formation; and stabilization of the genome. Another seventeen studies find that magnesium has a crucial role in control of calcium uptake, subcellular content, and subcellular distribution in smooth muscle cells, endothelial cells, and cardiac muscle cells.
Magnesium Deficiency and Genotoxicity Summing up the role of magnesium in our genes, the Alturas point out that magnesium deficiency can induce cell cycle arrest (and senescence), can initiate programmed cell death, and is associated with DNA damage (genotoxic events). These magnesium- deficiency-related changes can occur in multiple cell types, including cardiac and vascular smooth muscle cells. Of note is that atherosclerotic plaque in the arterial walls of hypertensive patients shows considerable DNA damage, activation of DNA repair pathways, increased expression of p53 (a tumor suppressor protein), oxidation, apoptosis, and increased levels of ceramide (a waxy lipid).
In addition to the important role of therapeutic amounts of magnesium daily, diet, exercise and the quality of your mind space play roles in longevity and wellness. Tonight on my radio show we’ll disc
WIND: the allopathic medical establishment is wholly incompetent at preventing disease or improving health, remains willfully clueless on magnesium deficiency and nutrition in all forms, and remains committed to the hippocratic-oath-breaking mentality of one symptom / one diagnosis / one drug practices.
* Indeed the mainstream medical profession has in effect been about inducing disease and damaging health for decades now, by virtue of terrible advice on diet and heart health, along with total ignorance of nutrition and disdain for preventing illness in the first place by rigorous study. Instead the industry has become all about expensive drugs to treat preventable conditions. The medical establishment is utterly corrupt intellectually and ethically and financially. Talk to any honest MD and you’ll hear very disturbing things about how medicine is now practiced.